Pub. Date : 2006 Mar 1
PMID : 16444746
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: The objective of this study was to evaluate the ability of the clinically available histone deacetylase (HDAC) inhibitor valproate to enhance the cytotoxicity of the Bcr-Abl inhibitor imatinib in imatinib-resistant cell lines. | Valproic Acid | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Coexposure of cells to valproate and imatinib was associated with repression of several genes involved in Bcr-Abl transformation. | Valproic Acid | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | In particular, the combination valproate-imatinib downregulated the expression of Bcr-Abl and the antiapoptotic protein Bcl-2, which is particularly overexpressed in imatinib-resistant clones. | Valproic Acid | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |