Title : Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.

Pub. Date : 2006 May 1

PMID : 16442292






2 Functional Relationships(s)
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1 A series of analogs with nitro or serinamide substituents at the C-2"-, C-5"-, or C-6"-position of the combretastatin A-4 (CA4) B-ring was synthesized and evaluated for cytotoxic effects against heart endothelioma cells, blood flow reduction to tumors in SCID mice, and as inhibitors of tubulin polymerization. nitro carbonic anhydrase 4 Mus musculus
2 Several of these nitrogen-modified CA4 derivatives (both amino and nitro) demonstrate significant inhibition of tubulin assembly as well as cytotoxicity and in vivo blood flow reduction. nitro carbonic anhydrase 4 Mus musculus