Title : Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?

Pub. Date : 2005 Dec

PMID : 16441976






2 Functional Relationships(s)
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1 Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers. Lactic Acid solute carrier family 16 member 1 Homo sapiens
2 Lactate and H(+) are suggested to promote the sickling process in red blood cells (RBCs) containing hemoglobin S. We demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects, suggesting an involvement of MCT-1 in hemorheological disturbances in SCT carriers. Lactic Acid solute carrier family 16 member 1 Homo sapiens