Title : Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib.

Pub. Date : 2006 Feb

PMID : 16441427






2 Functional Relationships(s)
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1 Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib. Gefitinib mitogen-activated protein kinase 1 Homo sapiens
2 These results suggest that FN-induced activation of ERK, p38, Akt, cell proliferation and invasion was mediated, at least in part, via integrins, ADAM and EGFR, and that this FN-induced signaling pathway might be involved in the antimetastatic activity of gefitinib. Gefitinib mitogen-activated protein kinase 1 Homo sapiens