Pub. Date : 2006 Feb
PMID : 16441427
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib. | Gefitinib | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | These results suggest that FN-induced activation of ERK, p38, Akt, cell proliferation and invasion was mediated, at least in part, via integrins, ADAM and EGFR, and that this FN-induced signaling pathway might be involved in the antimetastatic activity of gefitinib. | Gefitinib | mitogen-activated protein kinase 1 | Homo sapiens |