Pub. Date : 2006
PMID : 16435076
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 2 | INTRODUCTION: Since the soluble receptor activator of the NF-kappaB ligand (sRANKL) as well as the endogenous anti-resorptive cytokine osteoprotegerin (OPG) are produced by osteoblasts and given that these cells undergo significant changes during antiresorptive treatment, we hypothesized that treatment with bisphosphonates (BP) would be accompanied by changes in serum OPG and sRANKL levels. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 3 | INTRODUCTION: Since the soluble receptor activator of the NF-kappaB ligand (sRANKL) as well as the endogenous anti-resorptive cytokine osteoprotegerin (OPG) are produced by osteoblasts and given that these cells undergo significant changes during antiresorptive treatment, we hypothesized that treatment with bisphosphonates (BP) would be accompanied by changes in serum OPG and sRANKL levels. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 4 | Univariate regression analysis demonstrated that changes in serum OPG levels after 12 months of BP treatment were positively and better correlated to BMD changes (trochanter: r=0.59, p<0.0001; neck: r=0.50, p<0.001) than those of sCTX, which showed the expected negative correlation to BMD change (trochanter: r=-0.35, p=0.03; neck: r=-0.23, p=0.16). | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 5 | CONCLUSIONS: We conclude that with BP treatment, changes in serum OPG levels, unlike changes in sCTX levels, are positively correlated to changes in BMD response. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 6 | The BP-related changes in serum OPG levels during treatment could result from effects on osteoclastogenesis and osteoclast apoptosis as well as from a direct stimulatory effect on osteoblastic OPG production. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 7 | The BP-related changes in serum OPG levels during treatment could result from effects on osteoclastogenesis and osteoclast apoptosis as well as from a direct stimulatory effect on osteoblastic OPG production. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |
| 8 | These changes in OPG levels may be used to predict the individual response of patients to BP treatment. | Diphosphonates | TNF receptor superfamily member 11b | Homo sapiens |