Title : Increased lipopolysaccharide-induced tissue factor activity and tumour necrosis factor production in monocytes after intake of aspirin: possible role of prostaglandin E2.

Pub. Date : 1992 Jun

PMID : 1643209






5 Functional Relationships(s)
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1 To determine how aspirin intake might influence lipopolysaccharide (LPS)-induced tissue factor (TF) activity and tumour necrosis factor (TNF) in human blood monocytes, we collected blood before and at various times after intake of 300 mg aspirin in 25 healthy volunteers. Aspirin coagulation factor III, tissue factor Homo sapiens
2 To determine how aspirin intake might influence lipopolysaccharide (LPS)-induced tissue factor (TF) activity and tumour necrosis factor (TNF) in human blood monocytes, we collected blood before and at various times after intake of 300 mg aspirin in 25 healthy volunteers. Aspirin coagulation factor III, tissue factor Homo sapiens
3 The rise in TF activity was maximal within 1 h after aspirin intake and no further rise was observed 3, 4 or 24 h after aspirin intake. Aspirin coagulation factor III, tissue factor Homo sapiens
4 In contrast, TF activity induced by incubating whole blood in the absence of LPS fell rapidly after the intake of aspirin. Aspirin coagulation factor III, tissue factor Homo sapiens
5 It is proposed that the increased LPS-induced TF activity and TNF production following aspirin intake may be due to suppressed PGE2 formation. Aspirin coagulation factor III, tissue factor Homo sapiens