Title : Target structure-based discovery of small molecules that block human p53 and CREB binding protein association.

Pub. Date : 2006 Jan

PMID : 16426974






3 Functional Relationships(s)
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1 Lysine acetylation of human tumor suppressor p53 in response to cellular stress signals is required for its function as a transcription factor that regulates cell cycle arrest, senescence, or apoptosis. Lysine tumor protein p53 Homo sapiens
2 Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage. Lysine tumor protein p53 Homo sapiens
3 Here, we report small molecules that block lysine 382-acetylated p53 association with the bromodomain of the coactivator CBP, an interaction essential for p53-induced transcription of the cell cycle inhibitor p21 in response to DNA damage. Lysine tumor protein p53 Homo sapiens