Title : Disproportionately elevated proinsulin levels in type 2 diabetic patients treated with sulfonylurea.

Pub. Date : 2006 Jan

PMID : 16425966






5 Functional Relationships(s)
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1 Disproportionately elevated proinsulin levels in type 2 diabetic patients treated with sulfonylurea. Sulfonylurea Compounds insulin Homo sapiens
2 The association between sulfonylureas administration and secretory function of pancreatic beta-cells, especially concerning insulin precursor peptides, is not sufficiently elucidated. Sulfonylurea Compounds insulin Homo sapiens
3 Preliminary studies by our research group revealed that the fasting proinsulin serum concentration is significantly higher in type 2 diabetic patients treated with sulfonylureas than in a well-matched group treated with insulin only. Sulfonylurea Compounds insulin Homo sapiens
4 Preliminary studies by our research group revealed that the fasting proinsulin serum concentration is significantly higher in type 2 diabetic patients treated with sulfonylureas than in a well-matched group treated with insulin only. Sulfonylurea Compounds insulin Homo sapiens
5 CONCLUSION: The disproportionately high proinsulin levels are due to sulfonylureas therapy. Sulfonylurea Compounds insulin Homo sapiens