Title : Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats.

Pub. Date : 2006 May 30

PMID : 16423372






1 Functional Relationships(s)
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1 Pretreatment with telithromycin significantly decreased the activity of 7-ethoxyresorufin O-deethylation and testosterone 6 beta-hydroxylation, suggesting that telithromycin decreases the activity of hepatic CYP1A2 and CYP3A2. ethoxyresorufin cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus