Title : Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.

Pub. Date : 2006 Jan 19

PMID : 16421574






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells. Cyclic AMP insulin Homo sapiens
2 In pancreatic beta-cells, cAMP potentiates Ca2+-dependent exocytosis and mediates the stimulation of insulin release exerted by the hormones glucagon and glucagon-like peptide-1 (GLP-1) (refs 4, 5-6). Cyclic AMP insulin Homo sapiens
3 Here we introduce a new ratiometric evanescent-wave-microscopy approach to measure cAMP concentration beneath the plasma membrane, and show that insulin-secreting beta-cells respond to glucagon and GLP-1 with marked cAMP oscillations. Cyclic AMP insulin Homo sapiens
4 Here we introduce a new ratiometric evanescent-wave-microscopy approach to measure cAMP concentration beneath the plasma membrane, and show that insulin-secreting beta-cells respond to glucagon and GLP-1 with marked cAMP oscillations. Cyclic AMP insulin Homo sapiens