Title : Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate.

Pub. Date : 2006 Mar

PMID : 16416302






2 Functional Relationships(s)
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1 Our aim was to predict quantitatively the drug-drug interaction (DDI) potential of five macrolides from in vitro studies using testosterone as the CYP3A substrate, and to compare the predictions generated from human liver microsomal and recombinant CYP3A4 data. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CONCLUSIONS: The DDI potential of five macrolide antibiotics was quantitatively predicted from in vitro studies using testosterone as the CYP3A substrate with HLM as the enzyme source. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens