Pub. Date : 2006 May
PMID : 16415089
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. | Clozapine | dopa decarboxylase | Mus musculus |
| 2 | A single dose of clozapine increased AAAD activity of striatum in a dose- and time-dependent manner. | Clozapine | dopa decarboxylase | Mus musculus |
| 3 | Acute clozapine increased tyrosine hydroxylase activity in striatum but with differing temporal patterns from AAAD and heightened dopamine metabolism. | Clozapine | dopa decarboxylase | Mus musculus |
| 4 | Chronically administered clozapine increased AAAD activity and protein and dopamine metabolism in striatum without affecting tyrosine hydroxylase. | Clozapine | dopa decarboxylase | Mus musculus |
| 5 | For the first time, these studies provide evidence that clozapine modulates AAAD activity in the brain and suggests that dopamine and serotonin receptors are involved. | Clozapine | dopa decarboxylase | Mus musculus |