Title : Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.

Pub. Date : 2006 Jan 23

PMID : 16412424






1 Functional Relationships(s)
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1 Antioxidants and SP600125, an inhibitor of JNK1/2, but not inhibitors of p38 MAPK and MEK1/2, significantly prevented cell death, thus implying that reactive oxygen species and JNK1/2 play crucial roles in the CEP-induced apoptosis of HuH-7 cells. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens