Title : [Experimental study on the mechanism of the apoptosis of leukemic cells induced by valproic acid].

Pub. Date : 2005 Dec

PMID : 16412349






3 Functional Relationships(s)
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1 After treatment with VPA, the level of caspase 3 in U937 increased from (14.09 +/- 1.19)% to (32.30 +/- 2.47)%, and caspase 8 from (4.58 +/- 1.41)% to (86.47 +/- 3.26)% (P < 0.01), but there was no significant change in caspase 9 [(13.25 +/- 3.11)% and (10.95 +/- 1.30)%]. Valproic Acid caspase 3 Homo sapiens
2 CONCLUSION: VPA could induce apoptosis of U937 through the activation of caspase 3 and 8; and it induced the apoptosis of Jurkat involving the activation of caspase 3 and 9. Valproic Acid caspase 3 Homo sapiens
3 CONCLUSION: VPA could induce apoptosis of U937 through the activation of caspase 3 and 8; and it induced the apoptosis of Jurkat involving the activation of caspase 3 and 9. Valproic Acid caspase 3 Homo sapiens