Title : Interactions of the neurotoxin MPTP and its demethylated derivative (PTP) with monoamine oxidase-B.

Pub. Date : 1992 Aug

PMID : 1641061






2 Functional Relationships(s)
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Protein Name
Organism
1 The conversion of MPTP to its corresponding pyridinium-ion derivative through the action of MAO-B is known to be essential for its neurotoxicity. pyridine monoamine oxidase B Homo sapiens
2 Studies of the changes in absorbance spectra during the MAO-B catalysed oxidation were consistent with the formation of the corresponding pyridinium-ion derivative (MPP+), which is known to be the effective neurotoxin, as the end-product when MPTP was oxidized. pyridine monoamine oxidase B Homo sapiens