Title : A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon.

Pub. Date : 2006 Apr

PMID : 16407467






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Furthermore, combined TauCl/5-ASA treatment additively inhibited TNF-dependent NF-kappaB activation. Mesalamine tumor necrosis factor Homo sapiens
2 Together, our data suggest that the colon-specific carrier taurine contributes to the clinical effect of the prodrug by potentiating the inhibitory effect of the active ingredient 5-ASA on a major proinflammatory signal, TNF-dependent NF-kappaB activation in the inflamed large intestine. Mesalamine tumor necrosis factor Homo sapiens