Title : Overexpression of cytosolic group IVA phospholipase A2 protects cells from Ca2+-dependent death.

Pub. Date : 2006 Mar 3

PMID : 16407173






3 Functional Relationships(s)
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1 Expression of a fusion protein containing the enhanced green fluorescent protein (EGFP) and human cytosolic Group IVA phospholipase A(2)alpha (EGFP-cPLA(2)alpha) in these cells prevents ionomycin-induced phosphatidylserine externalization and death. Ionomycin phospholipase A2 group IVA Homo sapiens
2 Cells expressing the cPLA(2)alpha mutant D43N, which does not bind calcium, retain their susceptibility to ionomycin-induced cell death. Ionomycin phospholipase A2 group IVA Homo sapiens
3 Both nonexpressing and EGFP-D43N-cPLA(2)alpha-expressing human embryonic kidney cells can be spared from ionomycin-induced cell death by pretreating them with exogenous arachidonic acid. Ionomycin phospholipase A2 group IVA Homo sapiens