Pub. Date : 2006 Sep
PMID : 16404634
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. | Sirolimus | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 2 | Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. | Sirolimus | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 3 | Therefore, the aim of this study was to determine whether the immunosuppressants cyclosporin A, tacrolimus and sirolimus are inhibitors and/or substrates of BCRP. | Sirolimus | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 4 | RESULTS: Cyclosporin A, tacrolimus and sirolimus significantly inhibited BCRP-mediated efflux of pheophorbide A, mitoxantrone and BODIPY-prazosin. | Sirolimus | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 5 | The EC(50) values of cyclosporin A, tacrolimus and sirolimus for inhibition of BCRP-mediated pheophorbide A efflux were 4.3 +/- 1.9 microM, 3.6 +/- 1.8 microM and 1.9 +/- 0.4 microM, respectively. | Sirolimus | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 6 | Cyclosporin A, tacrolimus and sirolimus also effectively reversed resistance of HEK cells to topotecan and mitoxantrone conferred by BCRP. | Sirolimus | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |