Title : Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo.

Pub. Date : 2006 May 1

PMID : 16397127






1 Functional Relationships(s)
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1 Selective inhibition of cyclooxygenase 2-dependent prostacyclin (by rofecoxib or etoricoxib) was associated with increased urinary excretion of 11-dehydro-TXB(2) in carriers of TLR4 polymorphisms, but not in wild-type, suggesting a restrainable effect of prostacyclin on platelet function in vivo in this setting. Etoricoxib toll like receptor 4 Homo sapiens