Title : Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure.

Pub. Date : 2006 Jan

PMID : 16394527






1 Functional Relationships(s)
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1 The values of total clearance (CL(tot)) of cyclosporin A, doxorubicin, tacrolimus and zonisamide in the CCl4-treated rats were decreased to about 1/2-1/3 of those in control rats. Tacrolimus C-C motif chemokine ligand 4 Rattus norvegicus