Pub. Date : 2005 Oct-Nov
PMID : 16393856
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 7 | The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |