Title : Stereoselective metabolism of rabeprazole-thioether to rabeprazole by human liver microsomes.

Pub. Date : 2006 Feb

PMID : 16389533






2 Functional Relationships(s)
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1 The mean K(m ) and V(max ) values of desmethylrabeprazole-thioether formation for CYP2C19 were 5.1 microM and 600 pmol/min/nmol of P450, respectively, whereas those for CYP2D6 were 15.1 microM and 736 pmol/min/nmol of P450, respectively. desmethylrabeprazole-thioether cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 The mean K(m ) and V(max ) values of desmethylrabeprazole-thioether formation for CYP2C19 were 5.1 microM and 600 pmol/min/nmol of P450, respectively, whereas those for CYP2D6 were 15.1 microM and 736 pmol/min/nmol of P450, respectively. desmethylrabeprazole-thioether cytochrome P450 family 2 subfamily B member 6 Homo sapiens