Title : Thioflavins released from nanoparticles target fibrillar amyloid beta in the hippocampus of APP/PS1 transgenic mice.

Pub. Date : 2006 Apr-May

PMID : 16386399






3 Functional Relationships(s)
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1 Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta). thioflavin T amyloid beta (A4) precursor protein Mus musculus
2 Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta). thioflavin T amyloid beta (A4) precursor protein Mus musculus
3 In the cortices of 7-14 months old APP/PS1 mice with age-dependent beta-amyloidosis, thioflavins selectively targeted fibrillar Abeta after biodegradation-induced release from their nanoparticulate carriers upon intracerebral injection. thioflavin T amyloid beta (A4) precursor protein Mus musculus