Title : Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.

Pub. Date : 2005 Nov

PMID : 16382042






1 Functional Relationships(s)
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1 Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells. sulindac sulfone cyclin D1 Homo sapiens