Pub. Date : 2005 Nov
PMID : 16382042
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC. | sulindac sulfone | catenin beta 1 | Homo sapiens |
| 2 | Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells. | sulindac sulfone | catenin beta 1 | Homo sapiens |
| 3 | These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin. | sulindac sulfone | catenin beta 1 | Homo sapiens |
| 4 | These data demonstrate that sulindac sulfone can modulate the APC/beta-catenin pathway in vitro and that its efficacy is dependent upon the mutational status of APC and beta-catenin. | sulindac sulfone | catenin beta 1 | Homo sapiens |