Pub. Date : 2006 Mar 3
PMID : 16380381
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we have identified the anti-apoptotic Bcl-2 family member Mcl-1 as a potent tBid-binding partner. | tBID | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Site-directed mutagenesis reveals that the Bcl-2 homology (BH)3 domain of tBid is essential for binding to Mcl-1, whereas all three BH domains (BH1, BH2, and BH3) of Mcl-1 are required for interaction with tBid. | tBID | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Site-directed mutagenesis reveals that the Bcl-2 homology (BH)3 domain of tBid is essential for binding to Mcl-1, whereas all three BH domains (BH1, BH2, and BH3) of Mcl-1 are required for interaction with tBid. | tBID | BCL2 apoptosis regulator | Homo sapiens |