Title : Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase.

Pub. Date : 2006 Feb 17

PMID : 16380078






2 Functional Relationships(s)
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1 Exposure of platelets to LDL or H2O2 led to phosphorylation of p38MAPK, its upstream regulator MAP kinase kinase 3/6 (MKK 3/6), and its downstream target heat shock protein 27 (HSP27), and this effect was abrogated in SKF86002-pretreated platelets. Hydrogen Peroxide mitogen-activated protein kinase kinase 3 Homo sapiens
2 Exposure of platelets to LDL or H2O2 led to phosphorylation of p38MAPK, its upstream regulator MAP kinase kinase 3/6 (MKK 3/6), and its downstream target heat shock protein 27 (HSP27), and this effect was abrogated in SKF86002-pretreated platelets. Hydrogen Peroxide mitogen-activated protein kinase kinase 3 Homo sapiens