Title : Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both.

Pub. Date : 2006 Apr 1

PMID : 16374778






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PMA, which mimics diacylglycerol (DAG) as an activator of cPKC, novel-PKC (nPKC), and non-PKC DAG-driven molecule(s), produced a dose-dependent dual effect on phagocytosis by CR3/MAC-1 and SRAI/II, i.e., augmentation at low concentrations and inhibition at high concentrations. Tetradecanoylphorbol Acetate teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens
2 Inhibition of phagocytosis by CR3/MAC-1 was enhanced by combining inhibiting concentrations of PMA with PKC inhibitors Go-6976 or Ro-318220, suggesting inhibition by PMA/DAG-driven non-PKC molecule(s). Tetradecanoylphorbol Acetate teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens