Pub. Date : 2005
PMID : 16372823
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lumiracoxib possesses a carboxylic acid group that makes it weakly acidic (acid dissociation constant [pKa] 4.7), distinguishing it from other selective COX-2 inhibitors. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | These data suggest that lumiracoxib may be associated with reduced systemic exposure, while still reaching sites where COX-2 inhibition is required for pain relief. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Major metabolites of lumiracoxib in plasma are the 5-carboxy, 4"-hydroxy and 4"-hydroxy-5-carboxy derivatives, of which only the 4"-hydroxy derivative is active and COX-2 selective. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Lumiracoxib is selective for COX-2 compared with COX-1 in the human whole blood assay with a ratio of 515 : 1 in healthy subjects and in patients with osteoarthritis or rheumatoid arthritis. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | COX-2 selectivity of lumiracoxib is associated with a reduced incidence of gastroduodenal erosions compared with naproxen and a lack of effect on both small and large bowel permeability. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |