Title : Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance.

Pub. Date : 2005

PMID : 16372821






2 Functional Relationships(s)
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1 Repaglinide is metabolised by CYP2C8 and, according to clinical studies, CYP2C8*3 carriers had higher clearance than carriers of the wild-type genotypes; however, this was not consistent with in vitro data and therefore further studies are needed. repaglinide cytochrome P450 family 2 subfamily C member 8 Homo sapiens
2 Repaglinide is metabolised by CYP2C8 and, according to clinical studies, CYP2C8*3 carriers had higher clearance than carriers of the wild-type genotypes; however, this was not consistent with in vitro data and therefore further studies are needed. repaglinide cytochrome P450 family 2 subfamily C member 8 Homo sapiens