Pub. Date : 2006 Mar
PMID : 16372380
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4, on the bioavailability and pharmacokinetics of sildenafil. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | These results indicate that coadministration of ciprofloxacin and clarithromycin significantly increased sildenafil bioavailability which can be attributed to the inhibitory effect of ciprofloxacin and clarithromycin on CYP3A4. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |