Title : Prevalence of unidirectional Na+-dependent adenosine transport and altered potential for adenosine generation in diabetic cardiac myocytes.

Pub. Date : 2006 May

PMID : 16369729






2 Functional Relationships(s)
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1 The activity of ecto-5"-nucleotidase increased 2-fold in diabetic cells resulting in a rise of the activity ratio of ecto-5"-nucleotidase/adenosine deaminase from 28 to 56.These results indicate that in rat cardiomyocytes diabetes alters activities of adenosine metabolizing enzymes in such a way that conversion of AMP to IMP is favored in the cytosolic compartment, whereas the capability to produce adenosine extracellularly is increased. Inosine Monophosphate 5' nucleotidase, ecto Rattus norvegicus
2 The activity of ecto-5"-nucleotidase increased 2-fold in diabetic cells resulting in a rise of the activity ratio of ecto-5"-nucleotidase/adenosine deaminase from 28 to 56.These results indicate that in rat cardiomyocytes diabetes alters activities of adenosine metabolizing enzymes in such a way that conversion of AMP to IMP is favored in the cytosolic compartment, whereas the capability to produce adenosine extracellularly is increased. Inosine Monophosphate 5' nucleotidase, ecto Rattus norvegicus