Pub. Date : 2005 Dec 29
PMID : 16366596
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Rasagiline is an irreversible, MAO B-selective inhibitor that has been approved as a novel anti-Parkinson"s drug. | rasagiline | monoamine oxidase B | Homo sapiens |
2 | In this study, we investigate the inhibition of recombinant human MAO A and MAO B by several rasagiline analogues. | rasagiline | monoamine oxidase B | Homo sapiens |
3 | The 1.7 A crystal structure of MAO B in complex with 4-(N-methyl-N-ethyl-carbamoyloxy)-N-methyl-N-propargyl-1(R)-aminoindan shows that the binding mode is similar to that of rasagiline with the carbamate moiety occupying the entrance cavity space. | rasagiline | monoamine oxidase B | Homo sapiens |
4 | 1(R)-Aminoindan, the major metabolic product of rasagiline, and its analogues reversibly inhibit both MAO A and MAO B. | rasagiline | monoamine oxidase B | Homo sapiens |
5 | The crystal structure of N-methyl-1(R)-aminoindan bound to MAO B shows that its aminoindan ring adopts a different orientation compared to that of rasagiline. | rasagiline | monoamine oxidase B | Homo sapiens |