Title : Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.

Pub. Date : 2005 Dec 29

PMID : 16366596






5 Functional Relationships(s)
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1 Rasagiline is an irreversible, MAO B-selective inhibitor that has been approved as a novel anti-Parkinson"s drug. rasagiline monoamine oxidase B Homo sapiens
2 In this study, we investigate the inhibition of recombinant human MAO A and MAO B by several rasagiline analogues. rasagiline monoamine oxidase B Homo sapiens
3 The 1.7 A crystal structure of MAO B in complex with 4-(N-methyl-N-ethyl-carbamoyloxy)-N-methyl-N-propargyl-1(R)-aminoindan shows that the binding mode is similar to that of rasagiline with the carbamate moiety occupying the entrance cavity space. rasagiline monoamine oxidase B Homo sapiens
4 1(R)-Aminoindan, the major metabolic product of rasagiline, and its analogues reversibly inhibit both MAO A and MAO B. rasagiline monoamine oxidase B Homo sapiens
5 The crystal structure of N-methyl-1(R)-aminoindan bound to MAO B shows that its aminoindan ring adopts a different orientation compared to that of rasagiline. rasagiline monoamine oxidase B Homo sapiens