Pub. Date : 2005 Dec 28
PMID : 16366565
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A stereoelectronic effect on turn formation due to proline substitution in elastin-mimetic polypeptides. | Proline | elastin | Homo sapiens |
| 2 | Calorimetric and spectroscopic investigations of these three polypeptides indicate that the incorporation of the substituted proline residues had a dramatic effect upon the self-assembly of the corresponding elastin peptide. | Proline | elastin | Homo sapiens |
| 3 | These results suggest that stereoelectronic effects could either enhance or hinder the self-assembly of elastin-mimetic polypeptides, depending on the influence of the proline analogue on the energetics of the beta-turn conformation that develops within the pentapeptide structural repeats above the phase transition. | Proline | elastin | Homo sapiens |
| 4 | The results of the these calculations suggested a similar outcome to the experimental data for the elastin-mimetic polypeptides, in that type II beta-turn structures were stabilized for peptide segments containing (2S,4R)-fluoroproline and destabilized for segments containing (2S,4S)-fluoroproline relative to the canonical proline residue. | Proline | elastin | Homo sapiens |