Title : Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism.

Pub. Date : 2005 Dec 15

PMID : 16357151






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Hydrogen peroxide was produced as a by-product of LOX activity and the removal of hydrogen peroxide by catalase treatment in invasive breast cancer cells led to a dose-dependent loss in Src activation. Hydrogen Peroxide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 Hydrogen peroxide was produced as a by-product of LOX activity and the removal of hydrogen peroxide by catalase treatment in invasive breast cancer cells led to a dose-dependent loss in Src activation. Hydrogen Peroxide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
3 These results suggest that LOX facilitates migration and cell-matrix adhesion formation in invasive breast cancer cells through a hydrogen peroxide-mediated mechanism involving the FAK/Src signaling pathway. Hydrogen Peroxide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens