Pub. Date : 2005 Nov-Dec
PMID : 16356124
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Curcumin inhibited the TPA-induced COX-2 expression at both transcriptional and post-transcriptional levels, and reduced the synthesis of prostaglandin E(2), one of the major products of COX-2. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Curcumin inhibited the TPA-induced COX-2 expression at both transcriptional and post-transcriptional levels, and reduced the synthesis of prostaglandin E(2), one of the major products of COX-2. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | Treatment of MCF10A cells with U0126, which is a pharmacological inhibitor of ERK1/2, reduced TPA-induced up-regulation of COX-2 and MMP-9. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |