Title : Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors.

Pub. Date : 1992 Jul

PMID : 1635556






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 5-Lipoxygenase-activating protein (FLAP) is specifically labeled by [125I]L-669,083 and [125I]L-691,678, photoaffinity analogues of two classes of potent leukotriene biosynthesis inhibitors. Leukotrienes arachidonate 5-lipoxygenase activating protein Homo sapiens
2 The roles that amino acid residues in the carboxyl-terminal half of the first hydrophilic loop of FLAP may play in the binding of leukotriene biosynthesis inhibitors are currently under investigation. Leukotrienes arachidonate 5-lipoxygenase activating protein Homo sapiens