Title : Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production.

Pub. Date : 2006 Mar

PMID : 16354768






1 Functional Relationships(s)
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1 Moreover, the JAK2 inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) abolished PA-induced IL-1beta and IL-6 release but not TNF-alpha production, which is consistent with the notion that IL-1beta and IL-6 but not TNF-alpha contain a STAT binding element in their promoter region. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide tumor necrosis factor Homo sapiens