Title : Interferon-alpha, zidovudine, and granulocyte-macrophage colony-stimulating factor: a phase I AIDS Clinical Trials Group study in patients with Kaposi's sarcoma associated with AIDS.

Pub. Date : 1992 Aug

PMID : 1634925






2 Functional Relationships(s)
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1 PURPOSE: To increase the hematologic tolerance of interferon-alpha (IFN alpha) and zidovudine combination therapy by the addition of granulocyte-macrophage colony-stimulating factor (GM-CSF), and to evaluate the safety, tolerance, and potential efficacy of the combination in patients with Kaposi"s sarcoma and AIDS. Zidovudine colony stimulating factor 2 Homo sapiens
2 CONCLUSIONS: GM-CSF prevents neutropenia induced by the IFN-alpha and zidovudine combination and induced no adverse effects on immune function or HIV activity. Zidovudine colony stimulating factor 2 Homo sapiens