Title : Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein.

Pub. Date : 1992 Jul 25

PMID : 1634508






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 smg GDS and rho GDI are stimulatory and inhibitory GDP/GTP exchange proteins, respectively, for a group of ras p21-related small GTP-binding proteins (G proteins). Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 smg GDS and rho GDI are stimulatory and inhibitory GDP/GTP exchange proteins, respectively, for a group of ras p21-related small GTP-binding proteins (G proteins). Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
3 rho p21 is a common substrate small G protein for both GDP/GTP exchange proteins. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
4 We examined here the functional interactions of these GDP/GTP exchange proteins with rho p21 as a substrate. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
5 Since the content of smg GDS was generally less than that of rho GDI in cells, these results suggest that there is some mechanism to release the inhibitory action of rho GDI and to make rho p21 sensitive to the smg GDS action during the conversion of rhoA p21 from the GDP-bound inactive form to the GTP-bound active form in intact cells. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens