Title : Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice.

Pub. Date : 2006 Jan

PMID : 16341840






1 Functional Relationships(s)
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1 AIMS/HYPOTHESIS: The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens