Title : Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase.

Pub. Date : 2005 Dec 15

PMID : 16335931






1 Functional Relationships(s)
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1 Changing the position of the nitro group from the "classical" meta- to the ortho-position relative to the side-chain substituent of the nitrocatechol pharmacophore exerted profound effects on selectivity and duration of COMT inhibition. nitrocatechol catechol-O-methyltransferase Homo sapiens