Title : Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression.

Pub. Date : 2005 Jul

PMID : 16335792






3 Functional Relationships(s)
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1 In HL-60 cells treated with 50 microM 18:1/DHA-PE and 200 microM dbcAMP for 24 h, the expression level of c-jun mRNA and c-Jun protein were remarkably elevated compared to cells treated with dbcAMP alone. Dihydroalprenolol Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In HL-60 cells treated with 50 microM 18:1/DHA-PE and 200 microM dbcAMP for 24 h, the expression level of c-jun mRNA and c-Jun protein were remarkably elevated compared to cells treated with dbcAMP alone. Dihydroalprenolol Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Thus, 18:1/DHA-PE might enhance dbcAMP-induced HL-60 cell differentiation and growth inhibition by regulation of c-jun and c-myc mRNA and their products. Dihydroalprenolol Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens