Pub. Date : 2005 Nov
PMID : 16334566
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methylation-specific bands of CpG islands in p16 gene" promoter were still existed in Huh-7 and T47D, while unmethylation-specific bands appeared in Huh-7 after the cells being treated with 25, 50, 75 and 100 micromol/ L of CDP for 6 days as well as in T47D after the cells being treated with 50, 75 and 100 micromol/L of CDP for 6 days. | Cytidine Diphosphate | cyclin dependent kinase inhibitor 2A | Homo sapiens |
| 2 | Methylation-specific bands of CpG islands in p16 gene" promoter were still existed in Huh-7 and T47D, while unmethylation-specific bands appeared in Huh-7 after the cells being treated with 25, 50, 75 and 100 micromol/ L of CDP for 6 days as well as in T47D after the cells being treated with 50, 75 and 100 micromol/L of CDP for 6 days. | Cytidine Diphosphate | cyclin dependent kinase inhibitor 2A | Homo sapiens |
| 3 | After the cells being treated with 50 micromol/L of CDP, the methylation-specific bands of CpG island in p16 gene" promoter were still existed in Huh-7 and T47D; unmethylation-specific bands appeared at 12 h and lasted to 144 h in Huh-7 while at 72 h and lasted to 144 h in T47D. | Cytidine Diphosphate | cyclin dependent kinase inhibitor 2A | Homo sapiens |
| 4 | CONCLUSION: CDP has inhibition effect on the cancer cell lines and has the ability to reverse the hypermethylated p16 gene promoter. | Cytidine Diphosphate | cyclin dependent kinase inhibitor 2A | Homo sapiens |