Title : Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle.

Pub. Date : 2006 Jan

PMID : 16331293






1 Functional Relationships(s)
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1 1.--The cardiostimulant effects of CGP12177, mediated through a beta(1)-adrenoceptor site with low affinity for (-)-propranolol, are potentiated by the nonselective PDE inhibitor IBMX but the role of PDE isoenzymes is unknown. Propranolol adrenoceptor beta 1 Rattus norvegicus