Pub. Date : 2005 Nov
PMID : 16321618
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND AND OBJECTIVE: Despite the belief that cytochrome P450 (CYP) 2D6 alone is responsible for the metabolism of risperidone, several studies suggest that CYP3A may be involved. | Risperidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The aim of this study was to evaluate the effect of itraconazole, a CYP3A inhibitor, on the plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients in relation to CYP2D6 genotype. | Risperidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CONCLUSIONS: Our results provide in vivo evidence of the involvement of CYP3A in the disposition of risperidone and 9-hydroxyrisperidone. | Risperidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | In addition to CYP2D6, treatment with CYP3A inhibitor(s) including itraconazole may influence clinical symptoms and risperidone side effects. | Risperidone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |