Title : Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone.

Pub. Date : 2005 Dec 28

PMID : 16321374






2 Functional Relationships(s)
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1 The aim of this study was to examine involvement of multidrug resistance gene (MDR1) C3435T and G2677T polymorphisms in release of cytokines from phythemaglutynin (PHA)-stimulated peripheral blood mononuclear cells, as well as treated with methotrexate or dexamethasone. Methotrexate ATP binding cassette subfamily B member 1 Homo sapiens
2 Moreover, determination of C3435T and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with methotrexate and dexamethasone. Methotrexate ATP binding cassette subfamily B member 1 Homo sapiens