Pub. Date : 2006 Mar
PMID : 16309716
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | CYP2B6 is a drug-metabolizing enzyme expressed in human tissues that can activate bupropion (a smoking cessation drug) and tobacco smoke nitrosamines and can inactivate drugs such as nicotine. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | We investigated the basal expression and the effect of chronic nicotine treatment on CYP2B6 protein in African Green monkey (Cercopithecus aethiops) brain. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Chronic nicotine treatment induced CYP2B6 expression in specific cells such as astrocytes and neurons in the frontal cortex, caudate, thalamus and hippocampus. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | In conclusion, CYP2B6 protein is expressed in specific cells in monkey brain and is induced by chronic nicotine treatment which may impact central metabolism of CYP2B6 substrates such as bupropion and nicotine. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | In conclusion, CYP2B6 protein is expressed in specific cells in monkey brain and is induced by chronic nicotine treatment which may impact central metabolism of CYP2B6 substrates such as bupropion and nicotine. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | In conclusion, CYP2B6 protein is expressed in specific cells in monkey brain and is induced by chronic nicotine treatment which may impact central metabolism of CYP2B6 substrates such as bupropion and nicotine. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 8 | In conclusion, CYP2B6 protein is expressed in specific cells in monkey brain and is induced by chronic nicotine treatment which may impact central metabolism of CYP2B6 substrates such as bupropion and nicotine. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |