Title : Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms.

Pub. Date : 2006 Jan 27

PMID : 16303758






5 Functional Relationships(s)
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Protein Name
Organism
1 We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS). Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
2 We and others have shown that POX is a p53-induced gene that can mediate apoptosis through generation of reactive oxygen species (ROS). Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
3 A time- and dose-dependent increase in POX catalytic activity was obtained in HCT116 cells treated with troglitazone with a concomitant increase in the production of intracellular ROS. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
4 Our results suggest that the induction of apoptosis by troglitazone may, at least in part, be mediated by targeting POX gene expression for generation of ROS by POX both by PPARgamma-dependent and -independent mechanisms. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
5 Our results suggest that the induction of apoptosis by troglitazone may, at least in part, be mediated by targeting POX gene expression for generation of ROS by POX both by PPARgamma-dependent and -independent mechanisms. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens