Title : Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells.

Pub. Date : 2005 Dec 30

PMID : 16289039






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1 In this study, PARP-1 activation by hydrogen peroxide decreased intracellular NAD+ levels in human pulmonary epithelial cells, which was found to be prevented in a dose-dependent manner by theophylline, a widely used compound in the treatment of COPD. Hydrogen Peroxide poly(ADP-ribose) polymerase 1 Homo sapiens